 许佩佩博士
主任医师
电话：邮箱：xu_peipei0618@163.com 地址：研究方向：
1、血小板等活细胞诊疗技术研发转化；2、恶性血液病的复发机制；3、人工智能与血液病。 1.中华医学会血液学分会青年委员会，常务委员 2.江苏省医学会血液学分会青年委员会，副主任委员 3.江苏省研究型医院协会浆细胞病专委会，委员兼秘书长 4.江苏省医师协会遗传分会，委员 5.南京市医学会血液学分会青年委员会，副主任委员 6.社会兼职：Annals of Blood、中国输血杂志等杂志section editor，BLOOD中文版、临床输血与检验、医学教育研究与实践等杂志编委，Nature communications等十余本杂志特约审稿人，国家自然基因通讯评审专家，江苏省等六省科技评审专家 1.ZMYND8 Reads H3K36me2 to Activate CEBPE Transcription and Suppress Multiple Myeloma Progression through the Inhibition of Adaptive UPR Pathways. Adv Sci (Weinh). 2025;12(20):e2409219. 2.A Novel Engineering Cell Therapy Platform Mimicking the Immune Thrombocytopenia-Derived Platelets to Inhibit Cytokine Storm in Hemophagocytic Lymphohistiocytosis. Adv Sci (Weinh). 2024;11(45):e2404571. 3.Transcriptional silencing of fetal hemoglobin expression by NonO. Nucleic Acids Res. 2021;49(17):9711-9723. 4.PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling. Genome Med. 2021;13(1):58. 5.PRMT5 regulates cell pyroptosis by silencing CASP1 in multiple myeloma. Cell Death Dis. 2021;12(10):851. 6.Semi-supervised enhanced discriminative local constraint preserving projection for dimensionality reduction of medical hyperspectral images. Comput Biol Med. 2023;167:107568. 7.Tailoring the component of protein corona via simple chemistry. Nat Commun. 2019;10(1):4520. 8.A novel mesenchymal stem cell-based regimen for acute myeloid leukemia differentiation therapy. Acta Pharm Sin B. 2023;13(7):3027-3042. 9.PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression. Theranostics. 2020;10(10):4437-4452. 10.JPlatinum prodrug nanoparticles inhibiting tumor recurrence and metastasis by concurrent chemoradiotherapy. J Nanobiotechnology. 2022;20(1):129. 11.Unsupervised dimensionality reduction of medical hyperspectral imagery in tensor space. Comput Methods Programs Biomed. 2023;240:107724. 12.Diagnostic performance of metagenomic next-generation sequencing among hematological malignancy patients with bloodstream infections after antimicrobial therapy. J Infect. 2025;90(2):106395. 13.The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer. NPJ Precis Oncol. 2023;7(1):28. 14.Screening T-Cell Activity via a Photodetachable DNA-Copolymer Nanocage and Its Therapeutic Application. Anal Chem. 2022;94(38):13205-13214. 15.Bifunctional iRGD-Exo-DOX crosses the blood-brain barrier to target central nervous system lymphoma. Biochem Pharmacol. 2024;223:116138. 16.TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer. Cell Death Differ. 2021;28(12):3316-3328. 17.Ultrafast glucose-responsive, high loading capacity erythrocyte to self-regulate the release of insulin. Acta Biomater. 2018;69:301-312. 18.Daunorubicin-Loaded CdTe QDs Conjugated with Anti-CD123 mAbs: A Novel Delivery System for Myelodysplastic Syndromes Treatment. Int J Nanomedicine. 2020;15:521-536. 19.Anti-RhoJ antibody functionalized Au@I nanoparticles as CT-guided tumor vessel-targeting radiosensitizers in patient-derived tumor xenograft model. Biomaterials. 2017;141:1-12. 20.Nitroxide-radicals-modified gold nanorods for in vivo CT/MRI-guided photothermal cancer therapy. Int J Nanomedicine. 2018;13:7123-7134. 21.Low-dose doxorubicin loaded extracellular vesicles combined Fas/FasL pathway-mediated chemo-sensitization and immunotherapy against tumor. Int J Pharm. 2024;660:124349. 22.Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues. Int Immunopharmacol. 2021;95:107567. 23.Correction to: Platinum prodrug nanoparticles inhibiting tumor recurrence and metastasis by concurrent chemoradiotherapy. J Nanobiotechnology. 2022;20(1):234. 24.Association of polymorphisms of cytosine arabinoside-metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia. Chin Med J (Engl). 2012;125(12):2137-2143. 25.Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine. 2012;7:789-798. 26.Neutrophil membranes coated, antibiotic agent loaded nanoparticles targeting to the lung inflammation. Colloids Surf B Biointerfaces. 2020;188:110755. 27.Identification of an RNA-binding perturbing characteristic for thiopurine drugs and their derivatives to disrupt CELF1-RNA interaction. Nucleic Acids Res. 2024;52(18):10810-10822. 28.Synergetic effect of functional cadmium-tellurium quantum dots conjugated with gambogic acid for HepG2 cell-labeling and proliferation inhibition. Int J Nanomedicine. 2013;8:3729-3736. 29.Protein-Confined Rotor Strategy for Quantum Yield Enhancement in Supramolecular Photosensitizers toward Sentinel Lymph Node-Targeted Photodynamic Immunoactivation. ACS Nano. 2025;19(27):24985-25006. 30.Apoptotic Mechanism of Human Leukemia K562/A02 Cells Induced by Magnetic Ferroferric Oxide Nanoparticles Loaded with Wogonin. Chin Med J (Engl). 2016;129(24):2958-2966. 31.Wogonin Inhibits Growth of Mantle Cell Lymphoma Cells through Nuclear Factor-κB Signaling Pathway. Chin Med J (Engl). 2018;131(4):495-497. 32.Daunorubicin and gambogic acid coloaded cysteamine-CdTe quantum dots minimizing the multidrug resistance of lymphoma in vitro and in vivo. Int J Nanomedicine. 2016;11:5429-5442. 33.Novel two-chain structure utilizing KIRS2/DAP12 domain improves the safety and efficacy of CAR-T cells in adults with r/r B-ALL. Mol Ther Oncolytics. 2021;23:96-106. 34.Anti-Fas Antibody Conjugated Nanoparticles Enhancing the Antitumor Effect of Camptothecin by Activating the Fas-FasL Apoptotic Pathway. ACS Appl Mater Interfaces. 2016;8(44):29950-29959. 35.Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells. Front Immunol. 2018;9:2038. 36.Polymorphisms of dihydropyrimidine dehydrogenase gene and clinical outcomes of gastric cancer patients treated with fluorouracil-based adjuvant chemotherapy in Chinese population. Chin Med J (Engl). 2012;125(5):741-746. 1.基于新型“CAR-血小板载药体系”的噬血细胞综合征免疫靶向治疗及机制研究，国家自然科学基金面上项目 2.PLP2调控细胞核形态在多发性骨髓瘤细胞“休眠-觉醒”中的作用及其临床意义，国家自然科学基金面上项目 3.生物活体功能材料的疾病治疗应用，国家重点研发计划子课题 4.新型功能化血小板再生的治疗作用及其机制研究，江苏省自然科学基金优秀青年项目 5.激活休眠骨髓瘤细胞的作用及其机制研究，中央高校原创与交叉研究基金培育项目 6.新型“人源化血小板载药体”实现噬血细胞综合征靶向治疗的机理与临床研究，中华人民共和国教育部/中央高校国际合作研究培育项目 1.基于人工智能的恶性血液病个体化诊疗策略体系构建与实施，省部级医学新技术引进奖，一等奖，2020年 2.基于免疫识别的靶向血小板载药体系在血液肿瘤的应用，中华医学会血液学分会最佳论文奖，一等奖，2019年 3.中华医学会第十七次会议全国血栓与止血学术会议最佳论文奖，2019年 4.血小板载化疗药物治疗恶性肿瘤的研究，江苏肿瘤医学科学技术奖，一等奖，2017年 5.CD22-血小板-DOX靶向载药系统的构建及其抗肿瘤效应研究，中华医学会第十六次全国血栓与止血会议“优秀大会发言”，二等奖，2017年 6.强心甾类固醇及纳米技术治疗淋巴系统肿瘤的基础及临床转化研究，南京市科学技术进步奖，三等奖，2017年 |